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    gpx7 glutathione peroxidase 7 [ Danio rerio (zebrafish) ]

    Gene ID: 552981, updated on 27-Mar-2024

    Summary

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    Official Symbol
    gpx7provided by ZNC
    Official Full Name
    glutathione peroxidase 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-419
    See related
    Ensembl:ENSDARG00000091511 AllianceGenome:ZFIN:ZDB-GENE-050522-419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6902827; zgc:112293
    Summary
    Predicted to enable peroxidase activity. Predicted to act upstream of or within response to oxidative stress. Is expressed in notochord and splanchnocranium. Orthologous to human GPX7 (glutathione peroxidase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (42219243..42231740, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (42763354..42775851, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 7b Neighboring gene family with sequence similarity 159 member A Neighboring gene terminal uridylyl transferase 4 Neighboring gene cytochrome P450, family 2, subfamily AA, polypeptide 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Knecht AL, et al. Toxicol Appl Pharmacol, 2013 Sep 1. PMID 23684558, Free PMC Article
    2. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mukaigasa K, et al. Mol Cell Biol, 2012 Nov. PMID 22949501, Free PMC Article
    3. Light- and clock-control of genes involved in detoxification. Carmona-Antoñanzas G, et al. Chronobiol Int, 2017. PMID 28617195
    4. Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Xu H, et al. Genes (Basel), 2020 Sep 24. PMID 32987694, Free PMC Article
    5. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Yin HM, et al. Sci Adv, 2020 May. PMID 32494702, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione peroxidase 7
    NP_001018337.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020501.1 → NP_001018337.1  glutathione peroxidase 7 precursor

      See identical proteins and their annotated locations for NP_001018337.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095737
      UniProtKB/TrEMBL
      Q502E1
      Related
      ENSDARP00000123903.2, ENSDART00000149944.2
      Conserved Domains (2) summary
      pfam00578
      Location:27 → 157
      AhpC-TSA; AhpC/TSA family
      cl00388
      Location:23 → 175
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      42219243..42231740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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